Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates

Posted on by Erik Young
Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates

Raising a heterologous tier 2 neutralizing antibody (nAb) response stays a daunting job for HIV vaccine growth. In this research, we explored the utility of numerous HIV-1 envelope (Env) immunogens in a sequential immunization scheme as a answer to this job. This exploration stemmed from the rationale that gp145, a membrane-bound truncation kind of HIV Env, could facilitate the focusing of induced antibody response on neutralizing epitopes when sequentially mixed with the soluble gp140 kind as immunogens in a prime-boost mode. We first confirmed that gp140 DNA prime-gp145 Tiantan vaccinia (TV) enhance probably represents a common format for inducing potent nAb response in mice.

However, when examined in rhesus macaque, this modality confirmed little effectiveness. To enhance the efficacy, we prolonged the unique modality by including a robust protein enhance, particularly native-like SOSIP.664 trimer displayed on ferritin-based nanoparticle (NP), which was generated by a newly developed click on method. The ensuing three-immunization routine succeeded in eliciting tier-2 nAb response with substantial breadth when carried out in rhesus macaque over a brief 8-week schedule. Importantly, the elicited nAb response was in a position to successfully comprise viremia upon a heterologous SHIV problem. Collectively, our research highlighted that diversification of Env immunogens, in each varieties and formulations, underneath the framework of a sequential immunization scheme would possibly open new alternative towards HIV vaccine growth.

An efficacious HIV-1 vaccine has remained an elusive goal for nearly 40 years. The sheer variety of the virus is one of the most important roadblocks for vaccine growth. HIV-1 often mutates and numerous strains predominate in numerous geographic areas, making the event of a globally relevant vaccine extraordinarily troublesome. Multiple approaches have been taken to overcome the problem of viral variety, together with sequence optimization, growth of consensus and mosaic sequences and the use of totally different prime-boost approaches. To develop an efficacious vaccine, these approaches may have to be mixed. One method to probably synergize these approaches is to use a rationally designed protein nanoparticle that enables for the native-like presentation of antigens, such because the self-assembling protein nanoparticle.

Parainfluenza Virus 5 Priming Followed by SIV/HIV Virus-Like-Particle Boosting Induces Potent and Durable Immune Responses in Nonhuman Primates

The seek for a preventive vaccine towards HIV an infection stays an ongoing problem, indicating the necessity for novel approaches. Parainfluenza virus 5 (PIV5) is a paramyxovirus replicating within the higher airways that isn’t related with any animal or human pathology. In animal fashions, PIV5-vectored vaccines have proven safety towards influenza, RSV, and different human pathogens. Here, we generated PIV5 vaccines expressing HIV envelope (Env) and SIV Gag and administered them intranasally to macaques, adopted by boosting with virus-like particles (VLPs) containing trimeric HIV Env. Moreover, we in contrast the immune responses generated by PIV5-SHIV prime/VLPs enhance routine in naïve vs a management group wherein pre-existing immunity to the PIV5 vector was established.

We display for the primary time that intranasal administration of PIV5-based HIV vaccines is protected, well-tolerated and immunogenic, and that boosting with adjuvanted trimeric Env VLPs enhances humoral and mobile immune responses. The PIV5 prime/VLPs enhance routine induced strong and sturdy systemic and mucosal Env-specific antibody titers with practical actions together with ADCC and neutralization. This routine additionally induced extremely polyfunctional antigen-specific T cell responses. Importantly, we present that diminished responses due to PIV5 pre-existing immunity may be overcome partly with VLP protein boosts.

Overall, these outcomes set up that PIV5-based HIV vaccine candidates are promising and warrant additional investigation together with transferring on to primate problem research. This blended strategies research aimed to consider the feasibility and preliminary efficacy of a totally automated, interactive smartphone-delivered intervention for smoking cessation amongst individuals dwelling with HIV in Cambodia. We used the explanatory sequential design, with a pilot two-group single-blind randomized managed trial (N = 50) adopted by in-depth interviews with all trial individuals. In the trial, individuals had been randomized to Standard Care (SC) or Automated Messaging (AM) group. SC comprised temporary recommendation to give up and self-help supplies.

Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates

Exploring HIV stigma amongst future healthcare suppliers in Indonesia

Future healthcare professionals are an vital group for interventions to get rid of HIV stigma within the well being workforce. Researchers examined HIV stigma and its relationship with healthcare self-discipline, HIV information, and religiosity amongst nursing, medical, and midwifery college students (N = 505) in three areas of Indonesia. In a multivariable linear mannequin, larger HIV stigma was related with male intercourse, decrease ranges of earnings and HIV information, and better ranges of religiosity. An interplay of healthcare self-discipline and province was additionally important. Medical college students in Jakarta had larger predicted stigma scores in contrast to nursing college students in Jakarta and in contrast to medical college students in different provinces.

Nursing college students in Papua had decrease predicted stigma scores in contrast to medical and midwifery college students in Papua and in contrast to nursing college students elsewhere. Strategies to cut back HIV stigma within the Indonesian well being workforce ought to embrace a robust deal with pre-clinical academic settings and contemplate public nursing establishments as offering attainable greatest apply fashions. Human immunodeficiency virus sort 1 (HIV-1) is principally transmitted by sexual activity, and efficient microbicides stopping HIV-1 transmission are nonetheless required.

Recombinant HIV-1 Envelope, His Tag
7-07589 500µg Ask for price

Recombinant HIV-1 Envelope, His Tag
7-07590 1000µg Ask for price

Recombinant HIV-1 Envelope (233)
7-07585 100µg Ask for price

Recombinant HIV-1 Envelope (233)
7-07586 500µg Ask for price

Recombinant HIV-1 Envelope (233)
7-07587 1000µg Ask for price

HIV 1 envelope recombinant antigen
00176-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV 1 envelope recombinant antigen. HIV-1 evnelope protein spanning the C-Terminus of gp 120 and most of gp 41.

HIV 1 envelope recombinant antigen
00176-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV 1 envelope recombinant antigen. HIV-1 evnelope protein spanning the C-Terminus of gp 120 and most of gp 41.

Recombinant HIV-2 Envelope
7-07744 100µg Ask for price

Recombinant HIV-2 Envelope
7-07745 500µg Ask for price

Recombinant HIV-2 Envelope
7-07746 1000µg Ask for price

Recombinant HIV-1 p24 His Tag
7-07606 5µg Ask for price

Recombinant HIV-1 p24 His Tag
7-07607 20µg Ask for price

Recombinant HIV-1 p24 His Tag
7-07608 1mg Ask for price

Recombinant HIV-1 gp41, His tag
7-07627 100µg Ask for price

Recombinant HIV-1 gp41, His tag
7-07628 500µg Ask for price

Recombinant HIV-1 gp41, His tag
7-07629 1000µg Ask for price

HIV 1, 2 envelope recombinant antigen
00175-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV 1, 2 envelope recombinant antigen. HIV-1 envelope conjugated to HIV-2 envelope peptide.

HIV 1, 2 envelope recombinant antigen
00175-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV 1, 2 envelope recombinant antigen. HIV-1 envelope conjugated to HIV-2 envelope peptide.

HIV type 1 Envelope protein [His]
DAG1511 100 µg
EUR 645

Recombinant HIV-1 Envelope conjugated to HIV-2 gp39
7-07711 100µg Ask for price

Recombinant HIV-1 Envelope conjugated to HIV-2 gp39
7-07712 500µg Ask for price

Recombinant HIV-1 Envelope conjugated to HIV-2 gp39
7-07713 1000µg Ask for price

Recombinant HIV Type-O Envelope
7-07714 100µg Ask for price

Recombinant HIV Type-O Envelope
7-07715 500µg Ask for price

Recombinant HIV Type-O Envelope
7-07716 1000µg Ask for price

Recombinant (E.Coli) HIV-2 Envelope
RP-573 100 ug
EUR 286

Recombinant HIV-1 p24 gag, His Tag
7-07609 100µg Ask for price

Recombinant HIV-1 p24 gag, His Tag
7-07610 500µg Ask for price

Recombinant HIV-1 p24 gag, His Tag
7-07611 1000µg Ask for price

HIV-1 gp41, His tag
E410A25-10 10μg
EUR 694

HIV-1 p24, His tag
E410A26-20 20μg
EUR 434

Recombinant HIV-1 gp 41 Envelope Protein
VAng-0532Lsx-inquire inquire Ask for price
Description: HIV type 1 Glycoprotein 41 Envelope Antigen, recombinant protein from E. coli, MW 146 kDa with Beta-galactosidase (114 kDa), 1.00 mg/mL.

HIV 1 Envelope gp41 Protein
abx060584-05mg 0.5 mg
EUR 940
  • Shipped within 5-10 working days.

HIV 1 Envelope gp41 Protein
abx060585-100ug 100 ug
EUR 1080
  • Shipped within 5-10 working days.

HIV-1 Envelope (233) Protein
20-abx260140
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

HIV type 1 Envelope protein
DAG1552 100 µg
EUR 645

Recombinant (E.Coli) HIV-1 Envelope conjugated to HIV-2 gp39
RP-564 100 ug
EUR 286

Recombinant HIV-2 gp36, His Tag
7-07738 100µg Ask for price

Recombinant HIV-2 gp36, His Tag
7-07739 500µg Ask for price

Recombinant HIV-2 gp36, His Tag
7-07740 1000µg Ask for price

Recombinant (E.Coli) HIV Type-O Envelope
RP-565 100 ug
EUR 286

HIV 2 Envelope Protein
abx060590-1mg 1 mg
EUR 1574
  • Shipped within 5-10 working days.

HIV-2 Envelope Protein
20-abx260147
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Recombinant (E.Coli, His-tag) HIV-1 pol Integrase
RP-555 10 ug
EUR 164

Recombinant (E.Coli, His-tag)HIV-1 p31 Integrase
RP-579 2 ug
EUR 164

Recombinant HIV-1 Envelope Protein, Untagged, E.coli-100ug
QP12241-100ug 100ug
EUR 218

Recombinant HIV-1 Envelope Protein, Untagged, E.coli-1mg
QP12241-1mg 1mg
EUR 1061

Recombinant HIV-1 Envelope Protein, Untagged, E.coli-500ug
QP12241-500ug 500ug
EUR 663

Recombinant HIV-1 gp41, MBP tag
7-07630 100µg Ask for price

Recombinant HIV-1 gp41, MBP tag
7-07631 500µg Ask for price

Recombinant HIV-1 gp41, MBP tag
7-07632 1000µg Ask for price

Recombinant Zika Envelope Protein, His, E.coli-100ug
QP13997-HIS-100ug 100ug
EUR 218

Recombinant Zika Envelope Protein, His, E.coli-10ug
QP13997-HIS-10ug 10ug
EUR 201

Recombinant Zika Envelope Protein, His, E.coli-1mg
QP13997-HIS-1mg 1mg
EUR 1261

Recombinant Zika Envelope Protein, His, E.coli-2ug
QP13997-HIS-2ug 2ug
EUR 155

Recombinant Zika Envelope Protein, His, E.coli-500ug
QP13997-HIS-500ug 500ug
EUR 663

Recombinant Zika Envelope Protein, His, E.coli-50ug
QP13997-HIS-50ug 50ug
EUR 545

HIV-1 Envelope conjugated to HIV-2 gp39 Protein
20-abx260144
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Recombinant (E.Coli, His-tag) HIV-1 gp120 nef Mosaic
RP-534 100 ug
EUR 286

Recombinant HIV HTLV-1 Envelope Protein, Untagged, E.coli-100ug
QP12353-100ug 100ug
EUR 218

Recombinant HIV HTLV-1 Envelope Protein, Untagged, E.coli-1mg
QP12353-1mg 1mg
EUR 1061

Recombinant HIV HTLV-1 Envelope Protein, Untagged, E.coli-500ug
QP12353-500ug 500ug
EUR 663

HIV 2 Envelope gp36 Protein
abx060591-1mg 1 mg
EUR 1358
  • Shipped within 5-10 working days.

HIV 2 Envelope gp36 Protein
abx060592-100ug 100 ug
EUR 1066
  • Shipped within 5-10 working days.

HIV Type-O Envelope Protein
20-abx260145
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

HIV type O envelope antigen
00178-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV type O envelope antigen. Synthetic HIV type-O peptide, containing the HIV type-O envelope-derived sequence.

HIV type O envelope antigen
00178-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV type O envelope antigen. Synthetic HIV type-O peptide, containing the HIV type-O envelope-derived sequence.

HIV 2 gp36 envelope antigen
00180-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV 2 gp36 envelope antigen. Synthetic HIV-2 Peptide containing the HIV-2 specific sequence of gp36.

HIV 2 gp36 envelope antigen
00180-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV 2 gp36 envelope antigen. Synthetic HIV-2 Peptide containing the HIV-2 specific sequence of gp36.

Recombinant HIV-2 gp36 Protein, His, E.coli-100ug
QP12269-HIS-100ug 100ug
EUR 201

Recombinant HIV-2 gp36 Protein, His, E.coli-1mg
QP12269-HIS-1mg 1mg
EUR 663

Recombinant HIV-2 gp36 Protein, His, E.coli-500ug
QP12269-HIS-500ug 500ug
EUR 463

Recombinant HIV-2 Envelope Protein, Untagged, E.coli-100ug
QP12267-100ug 100ug
EUR 218

Recombinant HIV-2 Envelope Protein, Untagged, E.coli-1mg
QP12267-1mg 1mg
EUR 1061

Recombinant HIV-2 Envelope Protein, Untagged, E.coli-500ug
QP12267-500ug 500ug
EUR 663

HCC-1 (CCL14) Human Recombinant Protein, His Tag
PROTQ16627-1 Regular: 10ug
EUR 317
Description: HCC-1 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 95 amino acids (20-93 a.a.) and having a molecular mass of 10.9kDa. The HCC-1 is purified by proprietary chromatographic techniques.

Recombinant (E.Coli) HIV-1 p24 >95% (no tag)
RP-536 10 ug
EUR 286

Recombinant HIV-2 gp36, MBP tag
7-07735 100µg Ask for price

Recombinant HIV-2 gp36, MBP tag
7-07736 500µg Ask for price

Recombinant HIV-2 gp36, MBP tag
7-07737 1000µg Ask for price

Envelope-1, Dengue Virus Subtype 1 Recombinant Protein, Insect Cells
PROTB1PNJ5-1 Regular: 10ug
EUR 317
Description: Recombinant Dengue Virus Subtype 1 produced in Insect Cells is a polypeptide chain containing amino acids 281-675 and having a molecular weight of approximately 50kDa. ;Dengue Envelope-1 is purified by proprietary chromatographic technique.

C5a (His-Tag), murine recombinant protein
P1112-.1 100 µg
EUR 962
Description: Mouse complement C5a is a 77-amino acid peptide and is generated during complement activation from the ?-chain of complement C5. Its molecular mass is 9 kDa. Mouse C5a shares 60% and 82% amino acid sequence identity to human C5a and rat C5a, respectively

C5a (His-Tag), murine recombinant protein
P1112-1 1 mg
EUR 6940
Description: Mouse complement C5a is a 77-amino acid peptide and is generated during complement activation from the ?-chain of complement C5. Its molecular mass is 9 kDa. Mouse C5a shares 60% and 82% amino acid sequence identity to human C5a and rat C5a, respectively

TXN1, Thioredoxin Recombinant Protein, His Tag
PROTP0AA25-1 Regular: 10ug
EUR 317
Description: Recombinant Thioredoxin produced in E.Coli is a single, non-glycosylated polypeptide chain containing 119 amino acids (2-109 a.a.) and having a molecular mass of 12.9kDa. TRX contains an amino acid His Tag N-terminus and is purified by proprietary chromatographic techniques.

Streptavidin, Streptavidin Recombinant Protein, His Tag
PROTP22629-1 Regular: 20ug
EUR 317
Description: Recombinant Streptomyces Avidinii Streptavidin produced in E.Coli is a single, non-glycosylated polypeptide chain (25-183) containing a total of 167 amino acids and having a molecular mass of 17kDa. The Streptavidin protein is fused to an 8 aa N-terminal His-Tag and purified by proprietary chromatographic techniques.

Visfatin Recombinant Protein Human, His Tag
PROTP43490-1 Regular: 25ug
EUR 317
Description: Visfatin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 511 amino acids and having a molecular mass of 57 kDa. ;The recombinant human Visfatin is fused to His tag at N-Terminus.

KLK1 Human, Kallikrein-1 Human Recombinant Protein, His Tag
PROTP06870-1 Regular: 10ug
EUR 317
Description: Kallikrein-1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 259 amino acids (25-262) and having a molecular mass of 28.7kDa.;KLK1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

NRN1 Human, Neuritin-1 Human Recombinant Protein, His Tag
PROTQ9NPD7-1 Regular: 10ug
EUR 317
Description: Neuritin-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Ala28-Gly116) containing 99 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 11.02kDa.

Human, LAG-1 (CCL4L1) Human Recombinant Protein, His Tag
PROTQ8NHW4-1 Regular: 20ug
EUR 317
Description: LAG-1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 94 amino acids (24-92 a.a.) and having a molecular mass of 10.5kDa (Molecular weight on SDS-PAGE will appear higher).;LAG-1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant HIV Type-O Envelope Protein, Untagged, E.coli-100ug
QP12237-100ug 100ug
EUR 218

Recombinant HIV Type-O Envelope Protein, Untagged, E.coli-1mg
QP12237-1mg 1mg
EUR 1061

Recombinant HIV Type-O Envelope Protein, Untagged, E.coli-500ug
QP12237-500ug 500ug
EUR 663

IL-1-alpha Interleukin-1 alpha Mouse Recombinant Protein, His Tag
PROTP01582-1 Regular: 20ug
EUR 317
Description: IL 1 alpha Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.4kDa.;IL 1 alpha is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

IL-1-alpha Interleukin-1 alpha Human Recombinant Protein, His Tag
PROTP01583-1 Regular: 20ug
EUR 317
Description: IL-1A Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 159 amino acids fragment (113-271) with an amino-terminal hexahistidine tag and having a total molecular mass of 22.5kDa. ;The Interleukin-1 alpha His-tag is purified by proprietary chromatographic techniques.

IL-1-beta Interleukin-1 beta Mouse Recombinant Protein, His Tag
PROTP10749-1 Regular: 25ug
EUR 317
Description: Interleukin-1 beta Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 189 amino acids and having a molecular mass of 21 kDa. ;The IL-1b is fused to His-Tag and purified by proprietary chromatographic techniques.

IL-1-alpha Interleukin-1 alpha Rat Recombinant Protein, His Tag
PROTP16598-1 Regular: 20ug
EUR 317
Description: IL 1 alpha Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (115-270 a.a) and having a molecular mass of 20.2kDa.

Recombinant HIV Type-O gp41, MBP tag
7-07720 100µg Ask for price

Recombinant HIV Type-O gp41, MBP tag
7-07721 500µg Ask for price

Recombinant HIV Type-O gp41, MBP tag
7-07722 1000µg Ask for price

TFF1 Human, Trefoil Factor-1 Human Recombinant Protein, His Tag
PROTP04155-1 Regular: 20ug
EUR 317
Description: TFF-1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 70 amino acids (25-84) which includes a 10 amino acid His Tag and having a total molecular mass of 7.9 kDa. ;TFF-1 Human Recombinant is purified by proprietary chromatographic techniques.

HIV-1 Tat Protein Peptide
B1433-1 1 mg
EUR 128
Description: HIV-1 Tat Protein Peptide

Human, Prolactin Human Recombinant Protein,His Tag
PROTP01236-1 Regular: 20ug
EUR 317
Description: Prolactin-His Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 199 amino acids fragment (29-227) and having a molecular mass of 23 kDa with an amino-terminal hexahistidine tag. ;The Prolactin is purified by proprietary chromatographic techniques.

RELM-Alpha Mouse Recombinant Protein, His Tag
PROTQ9EP95-1 Regular: 25ug
EUR 317
Description: RELM-alpha Mouse Recombinant is manufactured with a signal sequence of phage fd (20aa) and C-terminal fusion of flagTag (10aa). The RELM-alpha Flag-Tagged Fusion Protein is a 13.3 kDa protein containing 91 amino acid residues with 30 additional amino acid residues - signal sequence of phage fd, flagTag (underlined).

Human, Nanog Human Recombinant Protein, His Tag
PROTQ9H9S0-1 Regular: 20ug
EUR 317
Description: NANOG Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 174 amino acids (1-154) and having a molecular mass of 19.6 kDa.;The NANOG is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Human, Otoraplin Human Recombinant Protein, His Tag
PROTQ9NRC9-1 Regular: 20ug
EUR 317
Description: OTOR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 128 amino acids (26-128 a.a) and having a molecular mass of 14.3kDa. OTOR is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Human, AITRL Human Recombinant Protein, His Tag
PROTQ9UNG2-1 Regular: 20ug
EUR 317
Description: AITRL Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain (aa 50-177) containing a total of 137 amino acids and having a molecular mass of 15.6kDa. The AITRL protein is fused to a 9 aa His Tag at C-terminus and purified by proprietary chromatographic techniques.

Cyclophilin-B Human Recombinant Protein, His Tag
PROTP23284-1 Regular: 10ug
EUR 317
Description: Cyclophilin-B Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Asp34-Glu216) containing 193 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 22kDa.

Human, CD95 Human Recombinant Protein, His Tag
PROTP25445-1 Regular: 20ug
EUR 317
Description: Recombinant FAS antigen/ CD95 purified from E. coli is a single non-glycosilated polypeptide chain containing amino acids 157-320 of Fas antigen (base pairs 713-1190 of cDNA sequence). The recombinant CD95 is fused to C-terminal 6-histidine amino acids.;The FAS antigen is purified by proprietary chromatographic techniques.

Human, Leptin Human Recombinant Protein, His Tag
PROTP41159-1 Regular: 25ug
EUR 317
Description: Leptin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing amino acids 48-167 and having a total molecular mass of 19 kDa including the 4 kDa His tag.;The Leptin is purified by proprietary chromatographic techniques.

Enteropeptidase/ Enterokinase Bovine Recombinant Protein His Tag
PROTP98072-1 Regular: 100IU
EUR 524
Description: Enterokinase Bovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 2428.0kDa.;The Enterokinase Bovine is purified by proprietary chromatographic techniques.

Recombinant HTLV-1 Envelope
7-07753 100µg Ask for price

Recombinant HTLV-1 Envelope
7-07754 500µg Ask for price

Recombinant HTLV-1 Envelope
7-07755 1000µg Ask for price

Recombinant HIV-1 p24 Protein [His]
VAng-0527Lsx-inquire inquire Ask for price
Description: HIV type 1 P24 Antigen, recombinant protein from insect cell expression system.

Recombinant HIV-1 gp41 Protein [His]
VAng-0529Lsx-inquire inquire Ask for price
Description: HIV type 1 gp41 Antigen, recombinant protein from E. coli, MW 18.648 Da, 1.83 mg/mL.

Recombinant HIV-1 Gag Protein [His]
VAng-Lsx0260-100g 100 µg
EUR 594
Description: Recombinant HIV-1 Gag Protein, C-terminal 6xHis tagged, purified from E.coli.

Recombinant Human HIV-1 (group M, subA, HXB2) Envelope gp160 Protein, His-SUMO, E.coli-100ug
QP7356-ec-100ug 100ug
EUR 408

Recombinant Human HIV-1 (group M, subA, HXB2) Envelope gp160 Protein, His-SUMO, E.coli-10ug
QP7356-ec-10ug 10ug
EUR 200

Recombinant Human HIV-1 (group M, subA, HXB2) Envelope gp160 Protein, His-SUMO, E.coli-1mg
QP7356-ec-1mg 1mg
EUR 1632

Recombinant Human HIV-1 (group M, subA, HXB2) Envelope gp160 Protein, His-SUMO, E.coli-200ug
QP7356-ec-200ug 200ug
EUR 634

Recombinant Human HIV-1 (group M, subA, HXB2) Envelope gp160 Protein, His-SUMO, E.coli-500ug
QP7356-ec-500ug 500ug
EUR 1060

Recombinant Human HIV-1 (group M, subA, HXB2) Envelope gp160 Protein, His-SUMO, E.coli-50ug
QP7356-ec-50ug 50ug
EUR 263

IL-1RA Interleukin-1 Receptor Antagonist Human Recombinant Protein, His Tag
PROTP18510-1 Regular: 50ug
EUR 682
Description: IL1Ra Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.63kDa with an amino-terminal hexahistidine tag. ;The IL-1Ra His is purified by proprietary chromatographic techniques.

SUMO1 Small Ubiquitin-Related Modifier 1 Human Recombinant Protein, His Tag
PROTP63165-1 Regular: 20ug
EUR 317
Description: SUMO1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 109 amino acids (1-101) and having a molecular mass of 12.6 kDa.;SUMO1 is fused to a 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

IL1F10 Interleukin 1 Family, Member 10 Human Recombinant Protein, His Tag
PROTQ8WWZ1-1 Regular: 20ug
EUR 317
Description: IL1F10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 172 amino acids (1-152) and having a molecular mass of 19.1kDa.

EREG Human, Epiregulin Human Recombinant Protein, His Tag
PROTO14944-1 Regular: 25ug
EUR 317
Description: EREG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 69 amino acids (63-108 a.a) and having a molecular mass of 7.7kDa. EREG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Human, BRAK Human Recombinant Protein (CXCL14), His-Tag
PROTO95715-1 Regular: 5ug
EUR 317
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa. ;The Human BRAK contains a 10 a.a. fusion His tag at N-Terminus. ;The BRAK is purified by proprietary chromatographic techniques.

IP-10 Human Recombinant Protein (CXCL10), His Tag
PROTP02778-1 Regular: 25ug
EUR 317
Description: IP-10 His Tag Human Recombinant ?produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 77 amino acids fragment (22-98) and having a total molecular mass of 8.5 kDa with an amino-terminal hexahistidine tag. ;The IP-10 His is purified by proprietary chromatographic techniques.

SCGB1A1 Human, Uteroglobin Human Recombinant Protein, His Tag
PROTP11684-1 Regular: 10ug
EUR 317
Description: Uteroglobin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 80 amino acids and including a 10 a.a N-terminal His tag. The total molecular mass is 9.2kDa (calculated).

Human, Rantes Human Recombinant Protein (CCL5), His Tag
PROTP13501-1 Regular: 10ug
EUR 317
Description: Rantes Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 68 amino acids fragment (24-91) having a total molecular mass of 17.5kDa and fused with a 4.5kDa amino-terminal hexahistidine tag.;The Rantes His is purified by proprietary chromatographic techniques.

GRO-Beta Human Recombinant Protein (CXCL2), His Tag
PROTP19875-1 Regular: 10ug
EUR 317
Description: GRO-Beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 94 amino acids and having a molecular mass of 10.1 kDa. ;The GRO-b is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

GST, Glutathione S-Transferase Recombinant Protein, His Tag
PROTP26624-1 Regular: 50ug
EUR 317
Description: Recombinant Schistosoma japonicum GST full length protein contains 244 amino acids(1-224 a.a.) expressed in E.coli, having a molecular mass of 28.3kDa. ;The GST protein is fused to a 20 amino acids His-Tag at N-terminus. ;The GST protein is purified by proprietary chromatographic techniques.

Human, Lymphotactin Human Recombinant Protein (XCL1), His Tag
PROTP47992-1 Regular: 10ug
EUR 317
Description: XCL1 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 114 amino acids (22-114 a.a.) and having a molecular mass of 12.5 kDa. The XCL1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Human, Eotaxin Human Recombinant Protein (CCL11), His Tag
PROTP51671-1 Regular: 20ug
EUR 317
Description: Eotaxin His Tag Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 74 amino acids fragment (24-87) corresponding to the mature Eotaxin protein and having a molecular mass of 8345.9 Dalton with an amino-terminal hexahistidine tag.;The Eotaxin-His is purified by proprietary chromatographic techniques.

Human, GroES (HSP10) Human Recombinant Protein, His Tag
PROTP61604-1 Regular: 10ug
EUR 317
Description: GroES His Protein is 12.0 kDa protein containing 111 amino acid residues of the GroES Human and the 10 aa N-Terminal His-tag.

Human, Fractalkine Human Recombinant Protein (CX3CL1), His Tag
PROTP78423-1 Regular: 10ug
EUR 317
Description: Fractalkine Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 97 amino acids (25-100 a.a.) and having a molecular mass of 10.9kDa. ;The Fractalkine is purified by proprietary chromatographic techniques.

EPGN Human, Epigen Human Recombinant Protein, His Tag
PROTQ6UW88-1 Regular: 20ug
EUR 317
Description: EPGN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 111 amino acids (23-110 a.a) and having a molecular mass of 12.1kDa.

GRO-Gamma Mouse Recombinant Protein (CXCL3), His Tag
PROTQ6W5C0-1 Regular: 10ug
EUR 317
Description: GRO-g Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 98 amino acids (28-100 a.a.) and having a molecular mass of 10.6kDa.;CXCL3 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

HIV Infection Enhancer (Medium) (1 ml)
H901-1 NULL
EUR 0

Recombinant (E. coli) HIV-1 p24 gag (group M, subtype B, strain 92418, 133-363 aa) (27 kda, >95%, His-Tag)
RP-583-1 50 ug
EUR 286

Recombinant (HEK) HIV-1 gp120 (CN244, 36-511-aa, His-tag, 54 kda,
RP-1630 25 ug
EUR 408

Recombinant (HEK) HIV-1 gp120 (CN54, 27-498-aa, His-tag, 54 kda,
RP-1631 25 ug
EUR 408

Recombinant YFV Envelope protein [His]
DAGA-3030 0.1 mg
EUR 650

HIF1A Human, Hypoxia-Inducible Factor-1 Alpha Human Recombinant Protein,His Tag
PROTQ16665-1 Regular: 10ug
EUR 317
Description: HIF1A Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 231 amino acids (576-785 a.a.) and having a molecular mass of 25.1 kDa. The HIF1A is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Recombinant HIV-1 nef
7-07591 100µg Ask for price

Recombinant HIV-1 nef
7-07592 500µg Ask for price

Recombinant HIV-1 nef
7-07593 1000µg Ask for price

Recombinant HIV-1 p24
7-07603 100µg Ask for price

Recombinant HIV-1 p24
7-07604 500µg Ask for price

Recombinant HIV-1 p24
7-07605 1000µg Ask for price

Recombinant HIV-1 gp41
7-07624 100µg Ask for price

Recombinant HIV-1 gp41
7-07625 500µg Ask for price

Amphibian pores and skin is a wealthy supply of protection peptides with antiviral exercise. Here, we characterised a lectin-like peptide, fejerlectin (RLCYMVLPCP), remoted from the pores and skin of the frog Fejervarya limnocharis. Fejerlectin confirmed important hemagglutination and d-(+)-galacturonic acid-binding actions. Furthermore, fejerlectin suppressed the early entry of HIV-1 into goal cells by binding to the N-terminal heptad repeat of HIV-1 gp41 and stopping 6-HB formation and Env-mediated membrane fusion. Fejerlectin is the smallest lectin-like peptide recognized to date and represents a new and promising platform for anti-HIV-1 drug growth.