Exploration of a Sequential Gp140-Gp145 Immunization Regimen with Heterologous Envs to Induce a Protective Cross-Reactive HIV Neutralizing Antibody Response In Non-human Primates

Raising a heterologous tier 2 neutralizing antibody (nAb) response stays a daunting job for HIV vaccine growth. In this research, we explored the utility of numerous HIV-1 envelope (Env) immunogens in a sequential immunization scheme as a answer to this job. This exploration stemmed from the rationale that gp145, a membrane-bound truncation kind of HIV Read More

Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in two patients under antiretroviral therapy

One of the approaches to remedy human immunodeficiency virus (HIV) is the use of therapeutic vaccination. We have launched the Provir/Latitude 45 research to determine conserved CTL epitopes in archived HIV-1 DNA based on the HLA class I alleles in aviremic patients under antiretroviral therapy (ART). A HIV-1 polypeptidic therapeutic vaccine based mostly on viral Read More

Minimizing the Impact of the Triple Burden of COVID-19, Tuberculosis and HIV on Health Services in sub-Saharan Africa

In this angle, we talk about the affect of COVID-19 on tuberculosis (TB)/HIV well being companies and approaches to mitigating the rising burden of these three colliding epidemics in sub-Saharan Africa (SSA). SSA nations bear considerably excessive proportions of TB and HIV instances reported worldwide, in comparison with nations in the West. Whilst COVID-19 epidemiology Read More